According to Tallysight, a whopping 96% of experts are picking the 49ers to beat the Rams. It’s slightly better when factoring in the spread where the Rams are getting between 6.5 and 7.5 points, but only 35% of experts are taking them to cover the spread as underdogs.

Two NFC West teams renew their rivalry as we continue our NFL odds series with a 49ers-Rams prediction and pick.

The San Francisco 49ers (1-1) are 6.5-point favorites when they visit the Los Angeles Rams (0-2) in an NFC West matchup on Sunday, September 22, 2024 at SoFi Stadium.NFL odds courtesy of BetMGM

San Francisco 49ers quarterback Brock Purdy is still making quite an impact in the state of Iowa despite being three years removed from his playing days for the Cyclones.

San Francisco 49ers quarterback Brock Purdy isn't letting early-season injuries shake his confidence. Although he has been without reigning NFL Offensive Player of the Year Christian McCaffrey for the first two games—McCaffrey will miss at least the next three with Achilles tendinitis—Purdy remains optimistic.

In Purdy's last seven starts, he has won four games, lost three, thrown six touchdown passes and six interceptions, fumbled once and posted a passer rating of 87. That's about as average as it gets. And he's playing on the best team in football.